Semmelweis Publications
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    • Győrffy, Balázs Semmelweis University affiliated publications (2021-2026)

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    Number of publications: 182
    1.
    Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors
    Gyorffy, B
    D1
    INNOVATION
    2024.
    DOI:10.1016/j.xinn.2024.100625 (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    2.
    Web-Based Survival Analysis Tool Tailored for Medical Research (KMplot): Development and Implementation
    Lánczky, A;Gyorffy, B
    D1
    JOURNAL OF MEDICAL INTERNET RESEARCH
    2021.
    DOI:10.2196/27633 (Copy DOI)
    Semmelweis University authors: Lánczky, András, Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    3.
    Transcriptome-level discovery of survival-associated biomarkers and therapy targets in non-small-cell lung cancer
    Gyorffy, B
    D1
    BRITISH JOURNAL OF PHARMACOLOGY
    2024.
    DOI:10.1111/bph.16257 (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    4.
    Discovery and ranking of the most robust prognostic biomarkers in serous ovarian cancer
    Gyorffy, B
    D1
    GEROSCIENCE
    2023.
    DOI:10.1007/s11357-023-00742-4 (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    5.
    The role of the Mediterranean diet in reducing the risk of cognitive impairement, dementia, and Alzheimer's disease: a meta-analysis
    Fekete, M;Varga, P;Ungvari, Z;Fekete, JT;Buda, A;Szappanos, A;Lehoczki, A;Mozes, N;Grosso, G;Godos, J;Menyhart, O;Munkácsy, G;Tarantini, S;Yabluchanskiy, A;Ungvari, A;Gyorffy, B
    D1
    GEROSCIENCE
    2025.
    DOI:10.1007/s11357-024-01488-3 (Copy DOI)
    6.
    MetaAnalysisOnline.com: Web-Based Tool for the Rapid Meta-Analysis of Clinical and Epidemiological Studies
    Fekete, JT;Gyorffy, B
    D1
    JOURNAL OF MEDICAL INTERNET RESEARCH
    2025.
    DOI:10.2196/64016 (Copy DOI)
    Semmelweis University authors: Fekete, János Tibor, Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    7.
    TNMplot.com: A Web Tool for the Comparison of Gene Expression in Normal, Tumor and Metastatic Tissues
    Bartha, A;Gyorffy, B
    D1
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
    2021.
    DOI:10.3390/ijms22052622 (Copy DOI)
    8.
    Survival analysis across the entire transcriptome identifies biomarkers with the highest prognostic power in breast cancer
    Gyorffy, B
    D1
    COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
    2021.
    DOI:10.1016/j.csbj.2021.07.014 (Copy DOI)
    9.
    Pancancer survival analysis of cancer hallmark genes
    Nagy, A;Munkácsy, G;Gyorffy, B
    D1
    SCIENTIFIC REPORTS
    2021.
    DOI:10.1038/s41598-021-84787-5 (Copy DOI)
    Semmelweis University authors: Nagy, Ádám, Munkácsy, Gyöngyi, Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    10.
    A gene set enrichment analysis for cancer hallmarks
    Menyhart, O;Kothalawala, WJ;Gyorffy, B
    D1
    JOURNAL OF PHARMACEUTICAL ANALYSIS
    2025.
    DOI:10.1016/j.jpha.2024.101065 (Copy DOI)
    Semmelweis University authors: Menyhart, Otilia, Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    11.
    Adherence to the Mediterranean diet and its protective effects against colorectal cancer: a meta-analysis of 26 studies with 2,217,404 participants
    Ungvari, Z;Fekete, M;Fekete, JT;Grosso, G;Ungvari, A;Gyorffy, B
    D1
    GEROSCIENCE
    2025.
    DOI:10.1007/s11357-024-01296-9 (Copy DOI)
    12.
    Overweight and obesity significantly increase colorectal cancer risk: a meta-analysis of 66 studies revealing a 25-57% elevation in risk
    Ungvari, Z;Fekete, M;Varga, P;Lehoczki, A;Fekete, JT;Ungvari, A;Gyorffy, B
    D1
    GEROSCIENCE
    2025.
    DOI:10.1007/s11357-024-01375-x (Copy DOI)
    13.
    Autophagy and cancer drug resistance in dialogue: Pre-clinical and clinical evidence
    Qin, Y;Ashrafizadeh, M;Mongiardini, V;Grimaldi, B;Crea, F;Rietdorf, K;Gyorffy, B;Klionsky, DJ;Ren, J;Zhang, W;Zhang, XB
    D1
    CANCER LETTERS
    2023.
    DOI:10.1016/j.canlet.2023.216307 (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék, Department of Pediatrics,
    14.
    Predictive biomarkers of immunotherapy response with pharmacological applications in solid tumors
    Kovács, SA;Fekete, JT;Gyorffy, B
    D1
    ACTA PHARMACOLOGICA SINICA
    2023.
    DOI:10.1038/s41401-023-01079-6 (Copy DOI)
    15.
    Spatial predictors of immunotherapy response in triple-negative breast cancer
    Wang, XQ;Danenberg, E;Huang, CS;Egle, D;Callari, M;Bermejo, B;Dugo, M;Zamagni, C;Thill, M;Anton, A;Zambelli, S;Russo, S;Ciruelos, EM;Greil, R;Györffy, B;Semiglazov, V;Colleoni, M;Kelly, CM;Mariani, G;Del Mastro, L;Biasi, O;Seitz, RS;Valagussa, P;Viale, G;Gianni, L;Bianchini, G;Ali, HR
    D1
    NATURE
    2023.
    DOI:10.1038/s41586-023-06498-3 (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    16.
    Integrating artificial intelligence in drug discovery and early drug development: a transformative approach
    Ocana, A;Pandiella, A;Privat, C;Bravo, I;Luengo-Oroz, M;Amir, E;Gyorffy, B
    D1
    BIOMARKER RESEARCH
    2025.
    DOI:10.1186/s40364-025-00758-2 (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    17.
    Sleep disorders increase the risk of dementia, Alzheimer's disease, and cognitive decline: a meta-analysis
    Ungvari, Z;Fekete, M;Lehoczki, A;Munkácsy , G;Fekete, JT;Zábó , V;Purebl, G;Varga, P;Ungvari, A;Gyorffy, B
    D1
    GEROSCIENCE
    2025.
    DOI:10.1007/s11357-025-01637-2 (Copy DOI)
    18.
    Association between red and processed meat consumption and colorectal cancer risk: a comprehensive meta-analysis of prospective studies
    Ungvari, Z;Fekete, M;Varga, P;Lehoczki, A;Munkácsy, G;Fekete, JT;Bianchini, G;Ocana, A;Buda, A;Ungvari, A;Gyorffy, B
    D1
    GEROSCIENCE
    2025.
    DOI:10.1007/s11357-025-01646-1 (Copy DOI)
    19.
    Microenvironmental ammonia enhances T cell exhaustion in colorectal cancer
    Bell, HN;Huber, AK;Singhal, R;Korimerla, N;Rebernick, RJ;Kumar, R;El-derany, MO;Sajjakulnukit, P;Das, NK;Kerk, SA;Solanki, S;James, JG;Kim, D;Zhang, L;Chen, BD;Mehra, R;Frankel, TL;Gyorffy, B;Fearon, ER;di Magliano, MP;Gonzalez, FJ;Banerjee, R;Wahl, DR;Lyssiotis, CA;Green, M;Shah, YM
    D1
    CELL METABOLISM
    2023.
    DOI:10.1016/j.cmet.2022.11.013 (Copy DOI)
    20.
    Prognostic impact of glucagon-like peptide-1 receptor (GLP1R) expression on cancer survival and its implications for GLP-1R agonist therapy: an integrative analysis across multiple tumor types
    Ungvari, Z;Bartha, A;Ungvari, A;Fekete, M;Bianchini, G;Gyorffy, B
    D1
    GEROSCIENCE
    2025.
    DOI:10.1007/s11357-024-01494-5 (Copy DOI)
    21.
    Transient loss of Polycomb components induces an epigenetic cancer fate
    Parreno, V;Loubiere, V;Schuettengruber, B;Fritsch, L;Rawal, CC;Erokhin, M;Gyorffy, B;Normanno, D;Di Stefano, M;Moreaux, J;Butova, NL;Chiolo, I;Chetverina, D;Martinez, AM;Cavalli, G
    D1
    NATURE
    2024.
    DOI:10.1038/s41586-024-07328-w (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    22.
    Depression increases cancer mortality by 23-83%: a meta-analysis of 65 studies across five major cancer types
    Ungvari, Z;Fekete, M;Buda, A;Lehoczki, A;Fekete, JT;Varga, P;Ungvari, A;Györffy, B
    D1
    GEROSCIENCE
    2025.
    DOI:10.1007/s11357-025-01676-9 (Copy DOI)
    23.
    Impact of adherence to the Mediterranean diet on stroke risk
    Ungvari, Z;Fekete, M;Varga, P;Fekete, JT;Buda, A;Szappanos, A;Lehoczki, A;Mózes, N;Grosso, G;Menyhart, O;Munkácsy, G;Tarantini, S;Yabluchanskiy, A;Ungvari, A;Gyorffy, B
    D1
    GEROSCIENCE
    2025.
    DOI:10.1007/s11357-024-01491-8 (Copy DOI)
    24.
    Pathway-level mutational signatures predict breast cancer outcomes and reveal therapeutic targets
    Posta, M;Gyorffy, B
    D1
    BRITISH JOURNAL OF PHARMACOLOGY
    2025.
    DOI:10.1111/bph.70215 (Copy DOI)
    Semmelweis University authors: Posta, Máté, Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    25.
    Different mutations in SARS-CoV-2 associate with severe and mild outcome
    Nagy, A;Pongor, S;Gyorffy, B
    D1
    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
    2021.
    DOI:10.1016/j.ijantimicag.2020.106272 (Copy DOI)
    Semmelweis University authors: Nagy, Ádám, Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    26.
    Senescence-related genes as prognostic indicators in breast cancer survival
    Ungvari, Z;Ungvari, A;Fekete, M;Kiss, C;Gyorffy, B
    D1
    GEROSCIENCE
    2025.
    DOI:10.1007/s11357-024-01384-w (Copy DOI)
    27.
    The m6A writer RBM15 drives the growth of triple-negative breast cancer cells through the stimulation of serine and glycine metabolism
    Park, SH;Ju, JS;Woo, H;Yun, HJ;Lee, SB;Kim, SH;Gyorffy, B;Kim, EJ;Kim, H;Han, HD;Eyun, SI;Lee, JH;Park, YY
    D1
    EXPERIMENTAL AND MOLECULAR MEDICINE
    2024.
    DOI:10.1038/s12276-024-01235-w (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    28.
    Quantifying the impact of treatment delays on breast cancer survival outcomes: a comprehensive meta-analysis
    Ungvari, Z;Fekete, M;Buda, A;Lehoczki, A;Munkácsy, G;Scaffidi, P;Bonaldi, T;Fekete, JT;Bianchini, G;Varga, P;Ungvari, A;Gyorffy, B
    D1
    GEROSCIENCE
    2025.
    DOI:10.1007/s11357-025-01719-1 (Copy DOI)
    29.
    Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells
    Rosano, D;Sofyali, E;Dhiman, H;Ghirardi, C;Ivanoiu, D;Heide, T;Vingiani, A;Bertolotti, A;Pruneri, G;Canale, E;Dewhurst, HF;Saha, D;Slaven, N;Barozzi, I;Li, T;Zemlyanskiy, G;Phillips, H;James, C;Gyorffy, B;Lynn, C;Cresswell, GD;Rehman, F;Noberini, R;Bonaldi, T;Sottoriva, A;Magnani, L
    D1
    CANCER DISCOVERY
    2024.
    DOI:10.1158/2159-8290.CD-23-1161 (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    30.
    Multi-omics approaches in cancer research with applications in tumor subtyping, prognosis, and diagnosis
    Menyhárt, O;Gyorffy, B
    D1
    COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
    2021.
    DOI:10.1016/j.csbj.2021.01.009 (Copy DOI)
    31.
    Analysis of a large cohort of pancreatic cancer transcriptomic profiles to reveal the strongest prognostic factors
    Posta, M;Gyorffy, B
    D1
    CTS-CLINICAL AND TRANSLATIONAL SCIENCE
    2023.
    DOI:10.1111/cts.13563 (Copy DOI)
    32.
    Exercise and survival benefit in cancer patients: evidence from a comprehensive meta-analysis
    Ungvari, Z;Fekete, M;Varga, P;Munkácsy, G;Fekete, JT;Lehoczki, A;Buda, A;Kiss, C;Ungvari, A;Gyorffy, B
    D1
    GEROSCIENCE
    2025.
    DOI:10.1007/s11357-025-01647-0 (Copy DOI)
    33.
    Treatment delay significantly increases mortality in colorectal cancer: a meta-analysis
    Ungvari, Z;Fekete, M;Fekete, JT;Lehoczki, A;Buda, A;Munkácsy, G;Varga, P;Ungvari, A;Gyorffy, B
    D1
    GEROSCIENCE
    2025.
    DOI:10.1007/s11357-025-01648-z (Copy DOI)
    34.
    Imbalanced sleep increases mortality risk by 14-34%: a meta-analysis
    Ungvari, Z;Fekete, M;Varga, P;Fekete, JT;Lehoczki, A;Buda, A;Szappanos, A;Purebl, G;Ungvari, A;Gyorffy, B
    D1
    GEROSCIENCE
    2025.
    DOI:10.1007/s11357-025-01592-y (Copy DOI)
    35.
    Enhancing risk stratification models in localized prostate cancer by novel validated tissue biomarkers
    Olah, C;Mairinger, F;Wessolly, M;Joniau, S;Spahn, M;Julio, MKD;Hadaschik, B;Soós, A;Nyirády, P;Gyorffy, B;Reis, H;Szarvas, T
    D1
    PROSTATE CANCER AND PROSTATIC DISEASES
    2025.
    DOI:10.1038/s41391-024-00918-9 (Copy DOI)
    36.
    DNA methylation-based diagnostic, prognostic, and predictive biomarkers in colorectal cancer
    Müller, D;Gyorffy, B
    D1
    BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
    2022.
    DOI:10.1016/j.bbcan.2022.188722 (Copy DOI)
    Semmelweis University authors: Müller, Dalma, Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    37.
    muTarget: A platform linking gene expression changes and mutation status in solid tumors
    Nagy, A;Gyorffy, B
    Q1
    INTERNATIONAL JOURNAL OF CANCER
    2021.
    DOI:10.1002/ijc.33283 (Copy DOI)
    38.
    Prognostic significance of a signature based on senescence-related genes in colorectal cancer
    Ungvari, Z;Ungvari, A;Bianchini, G;Gyorffy, B
    D1
    GEROSCIENCE
    2024.
    DOI:10.1007/s11357-024-01164-6 (Copy DOI)
    39.
    MultipleTesting.com: A tool for life science researchers for multiple hypothesis testing correction
    Menyhart, O;Weltz, B;Gyorffy, B
    Q1
    PLOS ONE
    2021.
    DOI:10.1371/journal.pone.0245824 (Copy DOI)
    40.
    Inflammation and Colorectal Cancer: A Meta-Analysis of the Prognostic Significance of the Systemic Immune-Inflammation Index (SII) and the Systemic Inflammation Response Index (SIRI)
    Menyhart, O;Fekete, JT;Gyorffy, B
    D1
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
    2024.
    DOI:10.3390/ijms25158441 (Copy DOI)
    41.
    Unbiased Drug Target Prediction Reveals Sensitivity to Ferroptosis Inducers, HDAC and RTK Inhibitors in Melanoma Subtypes
    Pla, I;Szabolcs, BL;Péter, PN;Ujfaludi, Z;Kim, Y;Horvatovich, P;Sanchez, A;Pawlowski, K;Wieslander, E;Kuras, M;Murillo, JR;Guedes, J;Pál, DMP;Ascsillán, AA;Betancourt, LH;Németh, IB;Gil, J;de Almeida, NP;Szeitz, B;Szadai, L;Doma, V;Woldmar, N;Bartha, A;Pahi, Z;Pankotai, T;Gyorffy, B;Szasz, AM;Domont, G;Nogueira, F;Kwon, HJ;Appelqvist, R;Kárpáti, S;Fenyö, D;Malm, J;Marko-Varga, G;Kemény, LV
    Q1
    INTERNATIONAL JOURNAL OF DERMATOLOGY
    2025.
    DOI:10.1111/ijd.17586 (Copy DOI)
    42.
    Mediator kinase inhibition reverses castration resistance of advanced cancer
    Li, J;Hilimire, TA;Liu, YY;Wang, LL;Liang, JX;Gyorffy, B;Sikirzhytski, V;Ji, H;Zhang, L;Cheng, C;Ding, XK;Kerr, KR;Dowling, CE;Chumanevich, AA;Mack, ZT;Schools, GP;Lim, CU;Ellis, L;Zi, XL;Porter, DC;Broude, EV;McInnes, C;Wilding, G;Lilly, MB;Roninson, IB;Chen, MQ
    D1
    JOURNAL OF CLINICAL INVESTIGATION
    2024.
    DOI:10.1172/JCI176709 (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    43.
    Pan-cancer analysis of antibody-drug conjugate targets and putative predictors of treatment response
    Bosi, C;Bartha, A;Galbardi, B;Notini, G;Naldini, MM;Licata, L;Viale, G;Mariani, M;Pistilli, B;Ali, HR;Andre, F;Piras, M;Callari, M;Barreca, M;Locatelli, A;Vigano, L;Criscitiello, C;Pusztai, L;Curigliano, G;Gyorffy, B;Dugo, M;Bianchini, G
    Q1
    EUROPEAN JOURNAL OF CANCER
    2023.
    DOI:10.1016/j.ejca.2023.113379 (Copy DOI)
    Semmelweis University authors: Bartha, Áron, Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    44.
    Modulation of the Estrogen/erbB2 Receptors Cross-talk by CDK4/6 Inhibition Triggers Sustained Senescence in Estrogen Receptor- and ErbB2-positive Breast Cancer
    Viganò, L;Locatelli, A;Ulisse, A;Galbardi, B;Dugo, M;Tosi, D;Tacchetti, C;Daniele, T;Gyorffy, B;Sica, L;Macchini, M;Zambetti, M;Zambelli, S;Bianchini, G;Gianni, L
    D1
    CLINICAL CANCER RESEARCH
    2022.
    DOI:10.1158/1078-0432.CCR-21-3185 (Copy DOI)
    45.
    Oncogene-mediated metabolic gene signature predicts breast cancer outcome
    Aslan, M;Hsu, EC;Garcia-Marques, FJ;Bermudez, A;Liu, SQ;Shen, M;West, M;Zhang, CA;Rice, MA;Brooks, JD;West, R;Pitteri, SJ;Gyorffy, B;Stoyanova, T
    D1
    NPJ BREAST CANCER
    2021.
    DOI:10.1038/s41523-021-00341-6 (Copy DOI)
    46.
    The Immune-Related 27-Gene Signature DetermaIO Predicts Response to Neoadjuvant Atezolizumab plus Chemotherapy in Triple-Negative Breast Cancer
    Dugo, M;Huang, CS;Egle, D;Bermejo, B;Zamagni, C;Seitz, RS;Nielsen, TJ;Thill, M;Antón-Torres, A;Russo, S;Ciruelos, EM;Schweitzer, BL;Ross, DT;Galbardi, B;Greil, R;Semiglazov, V;Gyorffy, B;Colleoni, M;Kelly, CM;Mariani, G;Del Mastro, L;Blasi, O;Callari, M;Pusztai, L;Valagussa, P;Viale, G;Gianni, L;Bianchini, G
    D1
    CLINICAL CANCER RESEARCH
    2024.
    DOI:10.1158/1078-0432.CCR-24-0149 (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    47.
    Harnessing Hyperthermia: Molecular, Cellular, and Immunological Insights for Enhanced Anticancer Therapies
    Lukácsi, S;Munkácsy, G;Gyorffy, B
    Q1
    INTEGRATIVE CANCER THERAPIES
    2024.
    DOI:10.1177/15347354241242094 (Copy DOI)
    Semmelweis University authors: Munkácsy, Gyöngyi, Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    48.
    Prognostic impact of a senescence gene signature in multiple myeloma
    Lehoczki, A;Menyhart, O;Andrikovics, H;Fekete, M;Kiss, C;Mikala, G;Ungvari, Z;Gyorffy, B
    D1
    GEROSCIENCE
    2025.
    DOI:10.1007/s11357-025-01622-9 (Copy DOI)
    49.
    Inadequate sleep increases stroke risk: evidence from a comprehensive meta-analysis of incidence and mortality
    Ungvari, Z;Fekete, M;Lehoczki, A;Munkácsy, G;Fekete, JT;Zábó, V;Purebl, G;Varga, P;Ungvari, A;Gyorffy, B
    D1
    GEROSCIENCE
    2025.
    DOI:10.1007/s11357-025-01593-x (Copy DOI)
    50.
    PCSK9 expression and cancer survival: a prognostic biomarker at the intersection of oncology and geroscience
    Ungvari, Z;Menyhart, O;Lehoczki, A;Fekete, M;Bianchini, G;Gyorffy, B
    D1
    GEROSCIENCE
    2025.
    DOI:10.1007/s11357-025-01733-3 (Copy DOI)
    51.
    GTP Signaling Links Metabolism, DNA Repair, and Responses to Genotoxic Stress
    Zhou, WH;Zhao, ZT;Lin, A;Yang, JZ;Xu, J;Wilder-Romans, K;Yang, A;Li, J;Solanki, S;Speth, JM;Walker, N;Scott, AJ;Wang, L;Wen, B;Andren, A;Zhang, L;Kothari, AU;Yao, YY;Peterson, ER;Korimerla, N;Werner, CK;Ullrich, A;Liang, J;Jacobson, J;Palavalasa, S;O'Brien, AM;Elaimy, AL;Ferris, SP;Zhao, SG;Sarkaria, JN;Gyorffy, B;Zhang, SQ;Al-Holou, WN;Umemura, Y;Morgan, MA;Lawrence, TS;Lyssiotis, CA;Peters-Golden, M;Shah, YM;Wahl, DR
    D1
    CANCER DISCOVERY
    2024.
    DOI:10.1158/2159-8290.CD-23-0437 (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    52.
    The cell cycle-related genes RHAMM, AURKA, TPX2, PLK1, and PLK4 are associated with the poor prognosis of breast cancer patients
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    DOI:10.3389/fonc.2021.647269 (Copy DOI)
    Semmelweis University authors: Pongor, Lőrinc, Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    145.
    The prognostic significance of FOXC2 gene expression in cancer: A comprehensive analysis of RNA-seq data from the cancer genome atlas
    Hargadon, KM;Gyorffy, B;Strong, EW
    Q3
    CANCER GENETICS
    2021.
    DOI:10.1016/j.cancergen.2021.02.005 (Copy DOI)
    146.
    T-reg transcriptomic signatures identify response to check-point inhibitors
    Noblejas-López, MD;García-Gil, E;Pérez-Segura, P;Pandiella, A;Gyorffy, B;Ocaña, A
    Q1
    SCIENTIFIC REPORTS
    2024.
    DOI:10.1038/s41598-024-60819-8 (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    147.
    Identification of genetic fingerprint of type I interferon therapy in visceral metastases of melanoma
    Vizkeleti, L;Papp, O;Doma, V;Gil, J;Marko-Varga, G;Kovács, SA;Gyorffy, B;Kárpáti, S;Timár, J
    Q1
    SCIENTIFIC REPORTS
    2024.
    DOI:10.1038/s41598-024-77285-x (Copy DOI)
    148.
    Comprehensive analysis of differentially expressed miRNAs in hepatocellular carcinoma: Prognostic, predictive significance and pathway insights
    Smith, K;Beach, D;Silva, R;Balazs, G;Salani, F;Crea, F
    Q1
    PLOS ONE
    2024.
    DOI:10.1371/journal.pone.0296198 (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    149.
    Evaluating Individual Scientific Output Normalized to Publication Age and Academic Field Through the Scientometrics.org Project
    Gyorffy, B;Weltz, B;Munkácsy, G;Herman, P;Szabó, I
    Q1
    METHODOLOGY-EUROPEAN JOURNAL OF RESEARCH METHODS FOR THE BEHAVIORAL ANDSOCIAL SCIENCES
    2022.
    DOI:10.5964/meth.9463 (Copy DOI)
    150.
    Primary Founder Mutations in the PRKDC Gene Increase Tumor Mutation Load in Colorectal Cancer
    Pálinkás, HL;Pongor, L;Balajti, M;Nagy, A;Nagy, K;Békési, A;Bianchini, G;Vértessy, BG;Gyorffy, B
    D1
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
    2022.
    DOI:10.3390/ijms23020633 (Copy DOI)
    151.
    RIP140 Represses Intestinal Paneth Cell Differentiation and Interplays with SOX9 Signaling in Colorectal Cancer
    Gleizes, A;Triki, M;Bonnet, S;Baccari, N;Jimenez-Dominguez, G;Covinhes, A;Pirot, N;Blache, P;Yuan, R;Gyorffy, B;Cavaillès, V;Lapierre, M
    Q1
    CANCERS
    2021.
    DOI:10.3390/cancers13133192 (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    152.
    Proteotranscriptomic Discrimination of Tumor and Normal Tissues in Renal Cell Carcinoma
    Bartha, A;Darula, Z;Munkácsy, G;Klement, E;Nyirády, P;Gyorffy, B
    D1
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
    2023.
    DOI:10.3390/ijms24054488 (Copy DOI)
    153.
    Development and validation of a gene expression-based Breast Cancer Purity Score
    Barreca, M;Dugo, M;Galbardi, B;Gyorffy, B;Valagussa, P;Besozzi, D;Viale, G;Bianchini, G;Gianni, L;Callari, M
    D1
    NPJ PRECISION ONCOLOGY
    2024.
    DOI:10.1038/s41698-024-00730-7 (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    154.
    Genomic mapping of copy number variations influencing immune response in breast cancer
    López-Cade, I;García-Barberán, V;Morafraile, EC;Díaz-Tejeiro, C;Saiz-Ladera, C;Sanvicente, A;Segura, PP;Pandiella, A;Gyorffy, B;Ocaña, A
    Q2
    FRONTIERS IN ONCOLOGY
    2022.
    DOI:10.3389/fonc.2022.975437 (Copy DOI)
    155.
    Supporting grant reviewers through the scientometric ranking of applicants
    Gyorffy, B;Weltz, B;Szabó, I
    Q1
    PLOS ONE
    2023.
    DOI:10.1371/journal.pone.0280480 (Copy DOI)
    156.
    Transcriptomic Profiles of CD47 in Breast Tumors Predict Outcome and Are Associated with Immune Activation
    Noblejas-López, MD;Baliu-Piqué, M;Nieto-Jiménez, C;Cimas, FJ;Morafraile, EC;Pandiella, A;Corbi, AL;Gyorffy, B;Ocaña, A
    D1
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
    2021.
    DOI:10.3390/ijms22083836 (Copy DOI)
    157.
    Multi-gene assay 95- and 155-gene classifiers for prognosis prediction and chemotherapy omission in lymphnode positive luminal-type breast cancer
    Matsumoto, S;Tsunashima, R;Kitano, S;Watanabe, A;Kato, C;Morita, M;Sakaguchi, K;Gyorffy, B;Naoi, Y
    Q2
    CANCER TREATMENT AND RESEARCH COMMUNICATIONS
    2023.
    DOI:10.1016/j.ctarc.2023.100711 (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    158.
    Genomic Mapping of Epidermal Growth Factor Receptor and Mesenchymal-Epithelial Transition-Up-Regulated Tumors Identifies Novel Therapeutic Opportunities
    Paniagua-Herranz, L;Doger, B;Díaz-Tejeiro, C;Sanvicente, A;Nieto-Jiménez, C;Moreno, V;Segura, PP;Gyorffy, B;Calvo, E;Ocana, A
    Q1
    CANCERS
    2023.
    DOI:10.3390/cancers15123250 (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék, Department of Pediatrics,
    159.
    DNA methylation-me diate d extracellular matrix gene silencing in colorectal cancer
    Menyhart, O;Müller, D;Gyorffy, B
    Q1
    SEMINARS IN ONCOLOGY
    2026.
    DOI:10.1016/j.seminoncol.2026.152469 (Copy DOI)
    Semmelweis University authors: Menyhart, Otilia, Müller, Dalma, Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    160.
    NetMetaEasy: enabling rapid and user-friendly network meta-analysis (NMA) for comparative effectiveness research
    Fekete, JT;Komócsi, A;Gyorffy, B
    D1
    BRITISH JOURNAL OF PHARMACOLOGY
    2026.
    DOI:10.1111/bph.70391 (Copy DOI)
    Semmelweis University authors: Fekete, János Tibor, Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    161.
    Targeting the HMGB1-IL32 pathway to alleviate T cell exhaustion in epithelial ovarian cancer
    Murmu, A;Gyorffy, B
    D1
    GEROSCIENCE
    2025.
    DOI:10.1007/s11357-025-01963-5 (Copy DOI)
    Semmelweis University authors: Murmu, Ankita, Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    162.
    Impact pathway and gene ontology analyses of FOXC2-correlated genes in melanoma reveal a role for the FOXC2 transcription factor in several oncogenic pathways and processes
    Hargadon, KM;Györffy, B;Wall, JB
    Q3
    CLINICAL AND TRANSLATIONAL DISCOVERY
    2025.
    DOI:10.1002/ctd2.70104 (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    163.
    Comparative Evaluation of Mutect2, Strelka2, and FreeBayes for Somatic SNV Detection in Synthetic and Clinical Whole-Exome Sequencing Data
    Lopez-Cade, I;Gomez-Sanz, A;Sanvicente, A;Díaz-Tejeiro, C;Manzano, A;Pérez-Segura, P;Gyorffy, B;Ocaña, A;de la Hoya, M;García-Barberán, V
    Q1
    BIOMOLECULES
    2025.
    DOI:10.3390/biom15111532 (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    164.
    No detectable impact of short-term treatment delays on lung cancer survival
    Ungvari, Z;Fekete, M;Buda, A;Lehoczki, A;Fekete, JT;Munkácsy, G;Varga, P;Ungvari, A;Gyorffy, B
    D1
    GEROSCIENCE
    2025.
    DOI:10.1007/s11357-025-01684-9 (Copy DOI)
    165.
    NRF2 pathway activation predicts poor prognosis in lung cancer: a cautionary note on antioxidant interventions
    Ungvari, Z;Menyhart, O;Lehoczki, A;Fekete, M;Fazekas-Pongor, V;Ocana, A;Varga, P;Gyorffy, B
    D1
    GEROSCIENCE
    2025.
    DOI:10.1007/s11357-025-01736-0 (Copy DOI)
    166.
    Truncated DAPK Variants Restore Tumor Suppressor Activity and Synergize with Standard Therapies in High-Grade Serous Ovarian Cancer
    Raab, M;Gasimli, K;Gyorffy, B;Peña-Llopis, S;Becker, S;Sanhaji, M;Strebhardt, K
    Q1
    CANCERS
    2025.
    DOI:10.3390/cancers17121910 (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    167.
    Identification of Deregulated Proteins in Mutated BRCA1/2 Breast and Ovarian Cancers for Vectorized Biologics
    Sanvicente, A;Nieto-Jiménez, C;Morafraile, EC;Díaz-Tejeiro, C;Barberán, VG;Segura, PP;Balázs, G;Ocaña, A
    Q1
    CANCERS
    2025.
    DOI:10.3390/cancers17132208 (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    168.
    Chromatin Engagement and Transcriptional Activity of the ZNF217 Exon 4-Skipping Isoform Are Associated with Breast Cancer Aggressiveness and Bone Metastasis
    Fahmé, P;Bouazza, L;Croset, M;Ramadan, F;Croze, S;Riso, M;Ferraro, J;Clézardin, P;Peyruchaud, O;Lachuer, J;Gyorffy, B;Coleman, RA;Cohen, PA
    Q1
    CANCERS
    2026.
    DOI:10.3390/cancers18040664 (Copy DOI)
    Semmelweis University authors:
    Gyorffy, Balazs (Semmelweis Univ, Dept Bioinformat, H-1094 Bronx, Hungary.)
    Corresponding Author:Cohen, PA (corresponding author), Univ Lyon 1, Fac Medecine Lyon Est Domaine Laennec, F-69372 Lyon, France.; Cohen, PA (corresponding author), Fac Med Lyon Est, Res Unit UMR S1033, INSERM, LyOS, F-69372 Lyon, France.; Cohen, PA (corresponding author), Albert Einstein Coll Med Bronx, Dept Cell Biol, New York, NY 10461 USA.; Cohen, PA (corresponding author), Albert Einstein Coll Med Bronx, Gruss Lipper Biophoton Ctr, New York, NY 10461 USA.
    Semmelweis University authors: Győrffy, Balázs,
    169.
    Subtype-specific sirtuin expression signatures link mitochondrial-epigenetic networks to breast cancer survival
    Ungvari, Z;Menyhárt, O;Ocana, A;Lehoczki, A;Fekete, M;Bianchini, G;Gyorffy, B
    D1
    GEROSCIENCE
    2026.
    DOI:10.1007/s11357-026-02143-9 (Copy DOI)
    170.
    Clinical and Immunologic Characteristics of Colorectal Cancer Tumors Expressing LY6G6D
    García, AS;Pedregal, M;Paniagua-Herranz, L;Diaz-Tejeiro, C;Nieto-Jiménez, C;Segura, PP;Munkacsy, G;Gyorffy, B;Calvo, E;Moreno, V;Ocaña, A
    D1
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
    2024.
    DOI:10.3390/ijms25105345 (Copy DOI)
    171.
    In silico evaluation of the immunogenic profile of lung cancers with SMARCA4 genetic alterations
    Nieto-Jiménez, C;Garcia-Lorenzo, E;Diaz-Tejeiro, C;Paniagua-Herranz, L;Sanvicente, A;Doger, B;Moreno, I;Pedregal, M;Bartolomé, J;Manzano, A;Munkácsy, G;Gyorffy, B;Pérez-Segura, P;Calvo, E;Moreno, V;Ocana, A
    Q1
    SCIENTIFIC REPORTS
    2025.
    DOI:10.1038/s41598-025-02494-x (Copy DOI)
    Semmelweis University authors: Munkácsy, Gyöngyi, Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    172.
    Mortality, functional outcome, and bleeding risk after early versus delayed thrombectomy
    Ungvari, Z;Fekete, JT;Fekete, M;Lehoczki, A;Gulej, R;Sorond, F;Liotta, E;Prodan, CI;Toth, P;Kiss, C;Ungvari, A;Gyorffy, B
    D1
    GEROSCIENCE
    2026.
    DOI:10.1007/s11357-025-01915-z (Copy DOI)
    173.
    Prolonged survival in a patient with pbrm1 mutated metastatic cholangiocarcinoma receiving tazemetostat
    Pedregal, M;Morafraile, EC;Garrido, A;Doger, B;Hernandez, T;Morillo, D;Gyorffy, B;Ocaña, A;Minguez, P;Moreno, V
    D1
    NPJ PRECISION ONCOLOGY
    2025.
    DOI:10.1038/s41698-025-01113-2 (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    174.
    Understanding the Chemical Characteristics of Payloads and the Expression of Tumor-Associated Antigens of ADCs in Clinical Development
    Nieto-Jimenez, C;Paniagua-Herranz, L;Bosi, C;Poyatos-Racionero, E;Pedregal, M;Moreno, V;Calvo, E;Dominguez-Jurado, E;Hernandez, T;Perez-Segura, P;Gyorffy, B;Alonso-Moreno, C;Bianchini, G;Ocana, A
    Q1
    ACS OMEGA
    2025.
    DOI:10.1021/acsomega.5c09181 (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    175.
    Combining molecular patterns and clinical data for better immune checkpoint inhibitor prediction in metastatic urothelial carcinoma
    Váradi, M;Horváth, O;Soos, E;Csizmarik, A;Németh, B;Gyorffy, B;Kenessey, I;Reis, H;Koll, F;Oláh, C;Hadaschik, B;Krafft, U;Grünwald, V;Mairinger, F;Wessolly, M;Hoffmann, MJ;Grunewald, CM;Niegisch, G;Cotarelo, CL;Maráz, A;Kuthi, L;Szász, AM;Herold, Z;Posta, M;Bátai, B;Nyirády, P;Szarvas, T
    D1
    CANCER IMMUNOLOGY IMMUNOTHERAPY
    2025.
    DOI:10.1007/s00262-025-04224-8 (Copy DOI)
    176.
    Self-assembly of hybrid 3D cultures by integrating living and synthetic cells
    Piernitzki, N;Gao, N;Gasparoni, G;Krauss, LM;Schulze-Hentrich, J;Dustin, M;Schrul, B;Gyorffy, B;Mann, S;Staufer, O
    D1
    NATURE COMMUNICATIONS
    2025.
    DOI:10.1038/s41467-025-66789-3 (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    177.
    REST-dependent glioma progression occurs independently of the repression of the long non-coding RNA HAR1A
    Waters, E;Pucci, P;Rahman, R;Yatsyshyna, AP;Porter, H;Hirst, M;Gromnicova, R;Kraev, I;Mongiardini, V;Grimaldi, B;Golding, J;Fillmore, HL;Gyorffy, B;Gangadharannambiar, P;Velanis, CN;Heath, CJ;Crea, F
    Q1
    PLOS ONE
    2024.
    DOI:10.1371/journal.pone.0312237 (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    178.
    PPARγ acetylation governs mammary adenocarcinoma tumor growth via acetylated residues that determine DNA sequence-specific binding
    Tian, LF;Jiao, XM;Wang, CG;Li, DN;Ertel, A;Achinger-Kawecka, J;Addya, S;Soccio, RE;Chen, ER;Gyorffy, B;Di Sante, G;Zhong, ZJ;Alkhafaji, H;Entcheva, N;Campbell, EM;Mccue, PA;Kossenkov, AV;Pancsa, R;Tompa, P;Clark, SJ;Pestell, RG
    D1
    ONCOGENE
    2025.
    DOI:10.1038/s41388-025-03492-z (Copy DOI)
    Semmelweis University authors: Győrffy, Balázs, Pestell, Richard George,
    Semmelweis University departments: Semmelweis University, Faculty of Medicine, Bioinformatika Tanszék,
    179.
    A gyulladáshoz köthető jelátviteli utak fokozott aktivitása antraciklin-paklitaxel rezisztens emlőkarcinómákban
    Menyhárt, O; Fekete, János Tibor; Győrffy, Balázs;
    Q4
    MAGYAR ONKOLÓGIA 0025-0244 2060-0399
    2023.
    180.
    A unified platform enabling biomarker ranking and validation for 1562 drugs using transcriptomic data of 1250 cancer cell lines
    Fekete, JT;Gyorffy, B
    D1
    COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
    2022.
    DOI:10.1016/j.csbj.2022.06.007 (Copy DOI)
    181.
    PVT1 is a stress-responsive lncRNA that drives ovarian cancer metastasis and chemoresistance
    Tabury, K;Monavarian, M;Listik, E;Shelton, AK;Choi, AS;Quintens, R;Arend, RC;Hempel, N;Miller, CR;Györrfy, B;Mythreye, K
    D1
    LIFE SCIENCE ALLIANCE
    2022.
    DOI:10.26508/lsa.202201370 (Copy DOI)
    182.
    Mitochondrial dysfunction and immune suppression in BRAF V600E-mutated metastatic melanoma
    de Almeida, NP;Jánosi, AJ;Hong, RY;Rajeh, A;Nogueira, F;Szadai, L;Szeitz, B;Parada, IP;Doma, V;Woldmar, N;Guedes, J;Ujfaludi, Z;Bartha, A;Kim, Y;Welinder, C;Baldetorp, B;Kemény, LV;Pahi, Z;Wan, GH;Nguyen, N;Pankotai, T;Gyorffy, B;Pawlowski, K;Horvatovich, P;Szasz, AM;Sanchez, A;Kuras, M;Murillo, JR;Betancourt, L;Domont, GB;Semenov, YR;Yu, KH;Kwon, HJ;Németh, IB;Fenyo, D;Wieslander, E;Marko-Varga, G;Gil, J
    D1
    CLINICAL AND TRANSLATIONAL MEDICINE
    2024.
    DOI:10.1002/ctm2.1773 (Copy DOI)

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